Ep. 256 | How the Circadian Clock Impacts Kidney Function, Cardiovascular Health, & Predictive Homeostasis with Dr. Michelle Gumz
Dr. Michelle Gumz is an associate professor at the University of Florida. Her research focuses on the kidney's circadian clock and its relationship to cardiovascular health. In this episode, Dr. Gumz details how the circadian clock provides a mechanism for predictive homeostasis that directly impacts cardiovascular and kidney function. She also explains why normal sleep patterns are critical to long-term health outcomes.
ABOUT Dr. Michelle Gumz
Dr. Gumz has a long-time interest in the molecular control of renal function. The Gumz laboratory is investigating the role of the molecular circadian clock in the kidney with the long term goal of determining how the clock in the kidney contributes to the control of blood pressure as well as to overall cardiovascular health. Aldosterone is a mineralocorticoid hormone that regulates sodium balance and blood pressure. As a graduate student, Dr. Gumz was the first to identify the circadian clock gene Period 1 as an aldosterone target. She has subsequently shown that Period 1 regulates transcription of alpha ENaC, the aldosterone-regulated and rate-limiting subunit of the epithelial sodium channel. New areas of study include cross talk between the kidney clock and other tissue clocks and sex differences in the function of Period 1 and Bmal1, another critical core clock gene.
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